Cruz Bay, U.S. Virgin Islands is the main town on the island of Saint John in the United States Virgin Islands. It is the island's largest commercial center and the location of the main port on Saint John. Cruz Bay is also home to numerous shops and restaurants which are frequented by tourists and locals alike. The Virgin Islands National Park Visitor Center, the Elaine Sprauve Library, and a United States Post Office are also located in Cruz Bay.

Cruz Bay beach is lined with beach bars and shops. There is also a casino. The beach has soft white sand, a designated swimming area, and space for day boaters to anchor.